Protocol for the Weight-bearing in Ankle Fractures (WAX) trial: a multicentre prospective non-inferiority trial of early versus delayed weight-bearing after operatively managed ankle fracture, BMC Musculoskeletal Disorders
4.7 (522) In stock
Background Unstable ankle fractures represent a substantial burden of disease, accounting for a mean hospital stay of nine days, a mean cost of £4,491 per patient and 20,000 operations per year. There is variation in UK practice around weight-bearing instructions after operatively managed ankle fracture. Early weight-bearing may reduce reliance on health services, time off work, and improve functional outcomes. However, concerns remain about the potential for complications such as implant failure. This is the protocol of a multicentre randomised non-inferiority clinical trial of weight-bearing following operatively treated ankle fracture. Methods Adults aged 18 years and over who have been managed operatively for ankle fracture will be assessed for eligibility. Baseline function (Olerud and Molander Ankle Score [OMAS]), health-related quality of life (EQ-5D-5L), and complications will be collected after informed consent has been obtained. A randomisation sequence has been prepared by a trial statistician to allow for 1:1 allocation to receive either instruction to weight-bear as pain allows from the point of randomisation, two weeks after the time of surgery (‘early weight-bearing’ group) or to not weight-bear for a further four weeks (‘delayed weight -bearing’ group). All other treatment will be as per the guidance of the treating clinician. Participants will be asked about their weight-bearing status weekly until four weeks post-randomisation. At four weeks post-randomisation complications will be collected. At six weeks, four months, and 12 months post-randomisation, the OMAS, EQ-5D-5L, complications, physiotherapy input, and resource use will be collected. The primary outcome measure is ankle function (OMAS) at four months post-randomisation. A minimum of 436 participants will be recruited to obtain 80% power to detect a non-inferiority margin of -6 points on the OMAS 4 months post-randomisation. A within-trial health economic evaluation will be conducted to estimate the cost-effectiveness of the treatment options. Discussion The results of this study will inform national guidance with regards to the most clinically and cost-effective strategy for weight-bearing after surgery for unstable ankle fractures. Trial registration ISRCTN12883981 , Registered 02 December 2019.
Protocol for the Weight-bearing in Ankle Fractures (WAX) trial: a multicentre prospective non-inferiority trial of early versus delayed weight-bearing after operatively managed ankle fracture, BMC Musculoskeletal Disorders
Libro Pie Wagner, PDF, Foot
WAX — Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences
Bioengineering, Free Full-Text
Journal of Rehabilitation Medicine - A protocol for permissive weight- bearing during allied health therapy in surgically treated fractures of the pelvis and lower extremities - HTML
PDF) Protocol for the Weight-bearing in Ankle Fractures (WAX) trial: a multicentre prospective non-inferiority trial of early versus delayed weight-bearing after operatively managed ankle fracture
Weight bearing or non-weight bearing after surgically fixed ankle fractures, the WOW! Study: study protocol for a randomized controlled trial, Trials
Correction of ankle varus deformity using patient-specific dome-shaped osteotomy guides designed on weight-bearing CT: a pilot study
BMC Musculoskeletal Disorders 1/2021
Impact of Joint Laxity Before Total Knee Arthroplasty on Postoperative Ligament Balance
Journal of Rehabilitation Medicine - A protocol for permissive weight- bearing during allied health therapy in surgically treated fractures of the pelvis and lower extremities - HTML
PDF) Protocol for the Weight-bearing in Ankle Fractures (WAX) trial: a multicentre prospective non-inferiority trial of early versus delayed weight-bearing after operatively managed ankle fracture
Rebecca S Kearney's research works University of Bristol, Bristol (UB) and other places
PDF) Protocol for the Weight-bearing in Ankle Fractures (WAX) trial: a multicentre prospective non-inferiority trial of early versus delayed weight-bearing after operatively managed ankle fracture
Early Weight-Bearing Following Ankle Fracture ORIF
Minimally Invasive Treatment of Ankle Fractures in Patients at
Exercise or advice after ankle fractures (EXACT)
7 Broken ankle ideas exercise, senior fitness, workout
5 Must Use Plyometric Exercises for Gymnastics Knee and Ankle Rehabilitation
- Travis Scott Meltdown Lyrics, Timothee Chalamet, Kylie Jenner Dating Shade
- Hanes Ultimate Women's CofortSoft Waistband Cotton Stretch Hipster
- Cotton Maternity Bra - Undyed – MamaOwl
- 5 Pack Women Hip Lifting Cotton Panties M-5XL Plus Size Soft Panties High Waist Solid Stretch Briefs Underpants
- Esa Liang Shapewear for Women Tummy Control High Waisted Body Shaper Shorts Girdles Thigh Slimmer, Black(high-waist), X-Small-Small : : Clothing, Shoes & Accessories
- ZARA FAUX LEATHER MINI FLARED PANTS BLACK